Xanthohumol (XN) is a hop derived prenylated flavonoid contained in beer that shows promising chemopreventive properties that have been so far studied in the in vitro experiments. In this in vivo study we showed that dietary supplemetation of rats by XN supress amino-3-methyl-imidazo[4,5-f]quinoline (IQ)-induced DNA damage in colonocytes and hepatocytes and formation of preneoplastic foci in livers and colons of rats. Since the effects were observed with low doses of XN which are reached after consumption of brews with high XN levels, our findings may be relevant for humans.
COBISS.SI-ID: 2240591
This article presents an approach to microarray data analysis using discretised expression values in combination with a methodology of closed itemset mining for class labeled data (RelSets). The approach was validated on two independent sets of two-color microarray experiments using potato plants. Our results demonstrate that the two different analytical procedures, applied on the same data, are adequate for solving two different biological questions being asked. The used algorithms are freely available upon request to the authors.
COBISS.SI-ID: 2210383