Metka Filipič has been by the EFSA Management Board appointed to the CONTAM Panel, which brings together highly qualified experts. In 2010 she participated in the working group “Brominated flame retardants” in preparation of the risk assessment due to the presence of polibrominated flame retardants in food and in the working group »Genotoxicity testing strategies« in preparation of harmoniozed stratefies for genotoxicity testing in food products.
D.03 Membership in foreign/international boards/committees
COBISS.SI-ID: 2364239The invention relates to a method for determining genotoxicity of an agent and a cell based system useful therefore. In particular, the invention describes a biosensor system for detecting DNA damage in metabolically competent cell cultures. The proble the invention solves is rapid and sensitive measurement of genotoxicity using microtitreplate spectrofluorimeter. The assay system uses p53 competent, metabolically active HepG2 cells stably transfected with plasmid containing the DsRed reporter system under the control of p21 gene that is specifically upregulated in response to DNA damage.
F.06 Development of a new product
COBISS.SI-ID: 2328399