Trans-activation response DNA-binding protein (TDP-43) accumulation is the major component of ubiquitinated protein inclusions found in patients with amyotrophic lateral sclerosis. Authors propose that cellular apoptosis susceptibility protein associated defective nuclear transport may play a mechanistic role in the pathogenesis of the TDP-43 positive frontotemporal lobar degeneration.
COBISS.SI-ID: 23645223
Mycocypins inhibit their target cysteine protease by a unique mechanism. The crystal structures of the complex of clitocypin with the papain-like cysteine protease cathepsin V and of macrocypin and clitocypin alone have revealed yet another motif of binding to papain like-cysteine proteases, which in a yet unrevealed way occludes the catalytic residue.
COBISS.SI-ID: 23263527
Undesired alterations of the blood clotting balance may follow the intravascular injection of nanotherapeutics/diagnostics. It was demonstrated that highly PEGylated ORMOSIL-NPs and PEGylated PLGA NPs were particularly averse to the interaction with the soluble factors and cellular elements that may lead to intravascular blood coagulation.
COBISS.SI-ID: 2846833
Syntrophins are scaffold proteins that can bind signaling molecules and localize them to the plasma membrane. We demonstrate that in neuroblastoma SH-SY5Y cells, brain-specific ?1-syntrophin binds the neurotrophic factor ?-enolase through its PDZ domain, and translocates it to the plasma membrane. The cleavage of two amino acids at the C-terminal end of ?-enolase by cathepsin X prevents binding with the ?1-syntrophin PDZ domain and consequently, ?-enolase neurotrophic signalling.
COBISS.SI-ID: 2965617
Five different isolation techniques were combined with gas chromatographic-mass spectrometric determination of aroma compounds from buckwheat. Among all methods SDE was chosen as the most suitable technique to obtain the aroma compounds of cooked buckwheat.
COBISS.SI-ID: 33728005