The study was performed on arcive-derived genetic material. The analyis demonstrated relation between genetic polymorphism in methotrexate metabolic pathway and its plasma concentration during the treatment of acute lymphoblastic lekemia in children. Toxicity and treatment outcome was also analysed.
COBISS.SI-ID: 2793841
37 individuals with T1D and CD, 67 individuals with T1D and 70 controls were analyzed. An occurrence of CD in individuals with T1D was most significantly associated with B*08. The association with CD became stronger when B*08 was present in the DRB1*0301-DQB1*0201-DQA1*0501 (P = 5.00 x 10(-10)). We suggest a combined influence of alleles present in the MICA*008-B*08-A1-DR3-DQ2 extended haplotype on the development of CD in Slovenian individuals with T1D, where B*08 or/and a gene located close to it may play an important role, independently of HLA class II.
COBISS.SI-ID: 27616985
BMD in 55 children and adolescents (strict GFD) with negative EMA in the last 2 years was significantly higher than in 19 not strict GFD with positive EMA (lumbar p=0.01; total body p=0.005). There were significantly more patients with total body BMD below -1.0 in not strictly compliant group (p=0.03). Calcium intake and vitamin D levels were below recommendations in both groups. Patients on strict GFD are at risk for low BMD because of low calcium intake or vitamin D deficiency.
COBISS.SI-ID: 27648217
We report severely reduced IL-17F and IL-22 responses to Candida albicans antigens. Surprisingly, these reductions are strongly associated with neutralizing autoantibodies to IL-17F and IL-22. Our multicenter survey revealed neutralizing autoantibodies against IL-17A (41%), IL-17F (75%), and/ or IL-22 (91%) in )150 APECED patients. We conclude that IL-22 and IL-17F are key natural defenders against CMC and that the immunodeficiency underlying CMC in both patient groups has an autoimmune basis.
COBISS.SI-ID: 26737881
Overall, increased responses by IFN-gamma secreting cells were associated with lower beta-cell function whereas IL-5, IL-13 and IL-10 cytokine responses were positively associated with beta-cell function in adults and children. The number of detectable islet-reactive immune cells decreases within 1-2 years after diagnosis of type 1 diabetes. Cytokine production by antigen-specific PBMC reactivity is related to beta-cell function as measured by stimulated C-peptide. Cellular immunity appears to regress soon after disease diagnosis and begin of insulin therapy.
COBISS.SI-ID: 26761177