To date, venous thrombosis and arterial atherosclerotic disease were treated as two separated disease entities. However, our study demonstrated the existence of a tight association between venous thrombosis and arterial atherosclerotic disease. Thus, similar to the patients with atherosclerosis, patients with venous thrombosis exhibit an increased systemic inflammatory response and disturbances in the function of vascular wall , moreover, asymptomatic atherosclerotic changes in periferal arteries are more common in patients with venous thrombosis compared to healthy people.
COBISS.SI-ID: 26612441
We tested wheter noninvasive magnetic resonance imaging (MRI) can distinguish between retracted blood clots that are poorly susceptible to thrombolytic treatment and non-retracted blood clots that are more susceptible to thrombolytic treatment. A newer MRI method, apparent diffusion coefficient (ADC) mapping was found to better distinguish between retracted and nonretracted blood clots than the established method of T2 mapping. By ADC mapping we were able to depict retracted regions within blood clots that were poorly lysable by thrombolytic agents.
COBISS.SI-ID: 23046183
Heart failure is associated with hemostatic derrangements, which is reflected in increased levels of markers of coagulation and fibrinolysis. We have shown that tissue plasminogen actovator (tPA) and D-dimer predict cardiovascular mortality and hospitalizations; however, only tPA emerged as an independent predictor of prognosis after allowing for other possible confounders.
COBISS.SI-ID: 19652882
Heart failure is associated with subclinical inflammation, which is reflected in increased levels of inflammatory mediators. We have shown that interleukin-6 is a stronger predictor of heart failure related mortality and hospitalisations than high sensistive C-reactive protein.
COBISS.SI-ID: 1626399
Heart failure is associated with hemostatic derrangements, which is reflected in increased levels of markers of coagulation and fibrinolysis. We have shown that tissue plasminogen activator and its inhibitor (PAI-1) are similarly increased in both, systolic and diastolic heart failure, while D-dimer levels were significantly higher in patients with impaired left ventricular ejection fraction and in this respect paralelled NT-proBNP levels.
COBISS.SI-ID: 19809208