Determination of the functional capability of the peripheral arteries is increasingly used as an early marker of vessel disease. Flow-mediated brachial artery dilatation and the dilatation response to glyceryl trinitrate were measured using high-resolution ultrasound in patients with idiopathic venous thrombosis, and age-matched healthy controls. Compared to the control group, FMD was significantly reduced in the group of patients with idiopathic venous thrombosis. These results showed that idiopathic venous thrombosis is associated with impaired flow- and GTN-mediated vasodilatory response of the brachial artery. This may suggest involvement of the functional deterioration of the vessel wall in the pathogenesis of idiopathic VT and indicate a relationship between VT and atherothrombosis.
COBISS.SI-ID: 27716569
Plasmin is a direct-acting thrombolytic with a better safety profile than recombinant tissue-type plasminogen activator (rtPA). Thromboembolic fragments were retrieved from the intracranial carotid artery system of 15 patients with acute ischemic stroke and randomly assigned to ex vivo thrombolysis with plasmin or rtPA. Results of this study showed that retrieved human cerebral thromboemboli are amenable to ex vivo lysis by plasmin, the rate and degree of which was not different than that achieved with rtPA.
COBISS.SI-ID: 28967385
Inflammation plays a major pathogenetic role in the development of atherosclerotic plaques and related thromboembolic events. The identification of vulnerable plaques is of the utmost importance, as this may allow the implementation of more effective preventive and therapeutic interventions.Fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful for tracing inflammation within plaques. The results of our study show that FDG uptake is related to the accumulation of inflammatory cells in atherosclerotic lesions.This finding suggests that FDG uptake reflects the severity of atherosclerotic vessel wall inflammation,and in stenotic lesions, it could be an indicator of their vulnerability.
COBISS.SI-ID: 1267884
Coronary computed tomographic angiography (CCTA) is a promising non-invasive method for detection of coronary artery disease in individuals at intermediate cardiovascular risk. However, the influence of race and ethnicity on diagnostic performance CCTA has not been addressed to date. There were included patients who identified themselves as African-American, Hispanic/Latin, Asian or Caucasian and who underwent both CCTA and invasive coronary angiography. It was shown that 64-slice mutidetector CCTA is highly sensitive and specific in detecting significant coronary artery stenosis in individuals with chest pain irrespective of race or ethnicity.
COBISS.SI-ID: 31258329
PEITHO study is the first fibrinolytic study dealing with treatment of pulmory embolism in patients with moderate risk. The results are revived also in the latest guidelines on pulmonary embolism.
COBISS.SI-ID: 1451948