Osteoporotic fractures are major cause of disability and death. If we want to effectively prevent them, we should treat individuals at high risk of fracture. Primarily, we treat patients after osteoporotic vertebral or hip fracture, where it is required only to exclude secondary causes of osteoporosis prior to initiating treatment. For other women after menopause, the risk of fracture could be assessed using clinical factors, which are entered into the computer-driven FRAX algorithm. The measurement of bone mineral density could also be used, but we have to take into account the age and sex of subjects when interpreting the result. Treatment of osteoporosis requires a healthy lifestyle without smoking and excessive alcohol intake. The diet should be rich in calcium and protein. Regular physical exercise has positive effects on the bone as well as on the muscles and fall prevention. The addition of vitamin D is always recommended. Drugs have proven efficacy against osteoporotic fractures. We can choose between several inhibitors of bone resorption, such as estrogens, biophosphonates, raloxifene and denosumab. Teriparatide is an anabolic drug that promotes bone formation, while strontium ranelate has a beneficial effect on both processes of bone turnover.
F.18 Transfer of new know-how to direct users (seminars, fora, conferences)
COBISS.SI-ID: 4635711DNA microarrays are a molecular biology tool that enables genome wide analysis of gene expression. The basic principle has been used for at least three decades, however the recent advances in the fields of genetics, computer science and bioinformatics enabled the transition from the analysis of individual transcript to genomewide level.
F.04 Increase of the technological level
COBISS.SI-ID: 2669425Research group developed technological procedure that enables quick and precise determination of certain drugs and their metabolites in human plasma
F.09 Development of a new technological process or technology