The results this study demonstrate in vitro and in vivo that B. burgdorferi has greater inflammatory potential than B. afzelii and B. garinii, which may account in part for variations in the clinical manifestations of Lyme borreliosis.
COBISS.SI-ID: 26258905
Widespread awareness of Lyme borreliosis in Europe continues to grow due to increasing numbers of medical publications, information on the Internet, and from the media and patient support groups. The emphasis in scientific and medical publications has been on improvements in laboratory diagnostics, confirmation of therapeutic protocols, and the ecology of the vectors and pathogens.
COBISS.SI-ID: 26253273
Lyme borrelosis is a multi-systemic disease caused by Borrelia burgdorferi sensu lato. A complete presentation of the disease is an extremely unusual oberservation, in which a skin lesion follows a tick bite, the lesion itself is followed by heart and nervous system involvement, and later on by arthritis; late involvement of the eye, nervous system, joints and skin may also occur. Laboratory confirmation of a borrelial infection is needed for all manifestations of Lyme borreliosis, with the exception of typical erythema migrans skin lesions.
COBISS.SI-ID: 25565401
We present basic data pertinent to the current understanding of borrelial infection in pregnancy and propose a rationale for the management of Lyme borreliosis in pregnant women. We advocate early detection of attached ticks and their prompt removal but do not recommend the use of prophylactic antibiotics. We encourage the approach that antibiotic treatment of pregnant patients is restricted to those having a reliable clinical diagnosis of Lyme borreliosis, and propose intravenous antibiotic treatment with penicillin, or preferably ceftriaxone 2 g daily for 14 days.
COBISS.SI-ID: 25565657
We analyzed 74 B. afzelii and 113 B. garinii strains for the presence of flagellin, and outer surface proteins A, B and C. Differences in the presence, number, amount and molecular mass of analyzed proteins were found comparing isolates within particular species, according to species (B. afzelii and B. garinii) and according to origin (skin and CSF isolates). Distinctions in the synthesis of outer surface proteins may play a role in the dispersal of borreliae within and between animal reservoir and vector ticks, as well as in pathogenesis of Lyme borreliosis in humans.
COBISS.SI-ID: 25782489