The invention concerns new P-chiral phosphorus compounds with high enantiomeric purity where the phosphorus atom is bearer of chirality and is engaged in a 6-membered fused ring between a biphenylic structure; their metal complexes, and their application in asymmetric catalysis, in particular hydrogenation of unsaturated compounds. This technology allows easy access to enantiomerically enriched chiral molecules interesting in particular for the pharma, agrochemical, food, and cosmetic industries.
F.32 International patent
COBISS.SI-ID: 5194778Symposium with renowned international participation entitled “Trends in biomolecular structure: from chemistry to function” has been organized between October 3 and 5, 2013 in Ljubljana, Slovenia. The program of this international symposium included presentations and critical assessment of recent discoveries in the study of structure and dynamics of biological macromolecules using NMR. Symposium participants presented the results of their latest research in the fields of proteins, oligonucleotides and small molecules as well as their structural studies and application. The symposium gathered in one place the leading scientists who use NMR spectroscopy in their research. The symposium website is available at http://www.nmr.ki.si/trends_2013/.
B.01 Organiser of a scientific meeting
COBISS.SI-ID: 268860160In his Ph.D. thesis M. Trajkovski described folding of guanine rich DNA oligonucleotides into G-quadruplexes and studies of their structural characteristics and cation interactions. DNA oligonucleotide d[G2T2G2TGTG2T2G2] also known as “thrombin binding aptamer” (TBA) adopts G-quadruplex structures in the presence of K+ and Na+ ions. With the use of NMR, UV and CD spectroscopy he studied structural features of TBA and its cation interactions in the presence of 15NH4+, K+ and Na+ ions. He also studied interdependence of cation interactions and structural characteristics in d(TG8T)4, which is the longest tetramolecular G-quadruplex studied with high-resolution NMR spectroscopy and is herein used as a model to provide insights into the role of cations in the systems comprised of a number of consecutively stacked G-quartets. With the use of solution state NMR he showed that in the presence of 15NH4+ ions d(TG8T) adopts two G-quadruplex species in which all seven cation binding sites between the eight G-quartets are completely occupied. Potential applications requiring feasibility to control G-quadruplex fold are hindered due to the fact that the principles that govern the assembly of these tetrahelical structures are mostly unknown. He constructed the DNA oligonucleotide d[G3TG3T4G3T3G3] in order to design a unimolecular G-quadruplex with unprecedented folding topology. By the use of NMR spectroscopy he was able to confirm its folding topology. NMR spectroscopy and complementary biophysical methods enabled him to demonstrate that the oligonucleotide originating from the G-rich region from the first intron of the N-myc oncogene in the presence of K+, 15NH4+ and Na+ ions adopts G-quadruplex structures. In the presence of K+ ions he observed equilibrium between monomolecular and dimeric N-myc G-quadruplexes.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 266538752In an invited lecture at the conference with long tradition 12th Young Belgium Magnetic Resonance Scientist, which took place between 2nd-3rd December in Blankenberge, Belgium we presented our latest findings and results on G-quadruplex structural features and their interactions with cations. The lecture received a wonderful response.
B.04 Guest lecture
COBISS.SI-ID: 5398554As a result of hop breeding program in 2013, a new variety of hop (Humulus lupulus L.) with the name Styrian Eureka was entered in the catalog of hop varieties. According to its chemical characteristics and brewing value is clasified as dual purpose variety, usable for basic hoppoing and also for all late hoppings, that have especial influence oon beer flavor. Its characteristics are resistence to drought stress and to certain diseases.
F.32 International patent
COBISS.SI-ID: 620684