Heteroaromatics (furan, thiophene, isoxazole, thiazole) bearing hydroxyalkyl group were directly arylated using low-loading ligand-free Pd(OAc)2 (0.01-0.5 mol%) as precatalyst without any protection of hydroxy group. Reaction proceeded via activation of C-H bond of heteroaromate which was further functionalized with (hetero)aryl bromides thus selectively leading to 5-arylated products. Our methodology represents a more environmentally and economically attractive access to such arylated products in comparison with classical cross-coupling reactions. 7 independent SCI citations.
COBISS.SI-ID: 33849861
We have demonstrated a short, mild and chemoselective addition of organolithium reagents to BF2 complexes of beta-ketoesters yielding the corresponding 1,3-dioxa-BF2 complexes. The latter can be easily transformed into different 1,3-diketones. The method, in general, enables direct transformation of 3-oxopropenoates into the 1,3-diketones, which have great synthetic value in organic synthesis as starting material. In addition, the fluorescent properties of 1,3-dioxa-BF2 chelates were investigated.
COBISS.SI-ID: 34162181
In vivo amyloid PET imaging was carried out on symptomatic and asymptomatic carriers of PRNP mutations associated with the Gerstmann- Sträussler-Scheinker disease, a rare familial neurodegenerative disorder demonstrating prion amyloid pathology, using [18F]-FDDNP. The results demonstrate the feasibility of detecting prion protein accumulation in living patients with [18F]-FDDNP PET, and suggest an opportunity for its application to follow disease progression and monitor therapeutic interventions. Two independent citations.
COBISS.SI-ID: 30622469
We have demonstrated experimentally and theoretically how can 1,2,3-triazole (»Click triazole«) N2 nitrogen atom actively participate in coordination with different transition metal ions including Pt(II), Pd(II), Cu(II), Ru(II), Ag(I). Our theoretical study revealed that the stabilization of the resulting coordination compounds mostly originates in pi-back-donation from the metal to the aromatic ligand and to a lesser extent in electrostatic interactions, as previously reported in the literature. 8 independent SCI citations.
COBISS.SI-ID: 34066949
1-Picolyl-1,2,3-triazole has been identified as a versatile coordination ability ligand, allowing mono-, bi- and polidentate coordination to different metal ions, including those of rhodium, gold, palladium and mercury. Through the hydrogen-bonding, C–H•••pi and pi–pi stacking interactions, this ligand enables different supramolecular associations. 1-Picolyl-1,2,3-triazole, for example, stabilizes the formation of mercury coordination polymer, which is otherwise rarely observed. This article was listed among the journal's top "20 most read articles in November 2010".
COBISS.SI-ID: 34469381