In this article we investigated whether the level of fused late endocytic compartments affects the immunostimulatory capacity of hybridomas obtained by the electrofusion of dendritic and tumor cells. The level of fused late endocytic compartments was assessed and fused cells were then used for the priming of naive autologous T cells. The results demonstrate that in vitro cytotoxic T cell responses toward tumor cells are enhanced if a higher percentage of fused late endocytic compartments is present in the cell population of electrofused hybridoma cells.
COBISS.SI-ID: 25624281
In this review paper we present the latest knowledge about human papillomavirus (HPV) infection, HPV life cycle and HPV as a risk factor for cancer. Additionally, we discuss the functions of the viral proteins that appear to be the most appropriate for the development of therapeutics aimed at the treatment of viral infection and virus induced cancers.
COBISS.SI-ID: 1391099
We showed that DCs matured for over 20 hours can still induce a potent CTL response in spite of their decreased production of IL-12. We suggested that, apart from IL-12 production, concentration of co-stimulatory molecules on DCs is one of the decisive factors affecting their capacity to prime T cells. But even in the case of high concentration of co-stimulatory molecules on DCs, induction of CTLs still depends on CD4+ T cells.
COBISS.SI-ID: 21412647
On the 25th International Papillomavirus conference was presented how HPV-16 minor capsid protein L2 interacts with host sumoylation system, which is involved in modulation of diverse biological processes. We also identify the major SUMO binding site on L2 protein and showed that stabilization of the L2 might be one of the most important biological consequences of the L2 sumoylation. Organizers of the 25th International Papillomavirus and International Papillomavirus Society (IPV) selected abstract based on the above mentioned results for the IPV Travel Award.
COBISS.SI-ID: 1107195