We showed that DCs matured for over 20 hours can still induce a potent CTL response in spite of their decreased production of IL-12. We suggested that, apart from IL-12 production, concentration of co-stimulatory molecules on DCs is one of the decisive factors affecting their capacity to prime T cells. But even in the case of high concentration of co-stimulatory molecules on DCs, induction of CTLs still depends on CD4+ T cells.
F.02 Acquisition of new scientific knowledge
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