On the 25th International Papillomavirus conference was presented how HPV-16 minor capsid protein L2 interacts with host sumoylation system, which is involved in modulation of diverse biological processes. We also identify the major SUMO binding site on L2 protein and showed that stabilization of the L2 might be one of the most important biological consequences of the L2 sumoylation. Organizers of the 25th International Papillomavirus and International Papillomavirus Society (IPV) selected abstract based on the above mentioned results for the IPV Travel Award.
B.06 Other
COBISS.SI-ID: 1107195We showed that SUMO binding site is very conserved among different HPV types. We compared high and low risk HPV types (HPV-16 and HPV-11) and showed that both are clearly sumoylated by all three SUMO proteins, although the level of sumoylation vary significantly between HPV types and also between particular SUMO proteins. Differences in L2 sumoylation between high and low-risk HPV types suggest possible relevance of L2 sumoylation to the progression and outcome of an HPV infection. Abstract based on the above stated scientific data was selected for the oral presentation.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 1230075