In a study of 110 prostate cancer patients and 96 population controls, we examined the association between the CYP11A1 (TTTTA)n polymorphism and prostate cancer risk, aggressiveness and incidence of biochemical relapse after prostatectomy. Our results revealed no overall association of the (TTTTA)n polymorphism with cancer risk and aggressiveness. The presence of the (TTTTA)6 allele elevated the risk of biochemical relapse after prostatectomy. Moreover our findings suggest the (TTTTA)n polymorphism could be a potential microsatellite marker for the detection of early events in cancerogenesis.
COBISS.SI-ID: 25123289
Screening was performed in 7096 singleton pregnancies. The estimated risk for trisomy 21, the detection rate(DR), false positive rate(FPR) and the cut-off adequate to obtain a 5% false positive rate were calculated. The median maternal age was 28.6 years. The estimated risk for trisomy 21 was 1 in 300 or greater in 2.4%(171 of 7096) of all pregnancies and in 75%(9 of 12) of trisomy 21 pregnancies. The DR for all aneuploidies was 83.3%, for trisomy 21 75%. Screening for trisomy 21 in a low risk population in Slovenia gives comparable results to those in other countries.
COBISS.SI-ID: 23965913