Estimation of the glomerular filtration rate (GFR) is essential for the evaluation of patients with chronic kidney disease (CKD). The Cockcroft-Gault and MDRD formulas are serum creatinine-based equations, and the most widely used tests for renal function. The present study compares our own serum cystatin C-based equation and serum creatinine-based equations in patients with CKD. Our results indicate that serum cystatin C-based equation is a reliable marker of GFR with a very high diagnostic accuracy and ability to predict patients with CKD and GFR under 60/ml/min/1.73 m2.
COBISS.SI-ID: 3015487
Authors compared serum creatinine, creatinine clearance calculated from Cockcroft and Gault formula and serum cystatin C against 51CrEDTA clearance in 252 patients with CKD and GFR < 90 mL/min/1.73 m2. Analysis of correlations and diagnostic accuracy (receiver operating characteristic curves) of different GFR markers indicate that serum cystatin C is a more reliable marker of GFR in patients with CKD than serum creatinine.
COBISS.SI-ID: 2892607