Investigations into the immunogenicity of the prion protein are ongoing. To combat its pathological isoform without affecting the cellular prion protein is a challenge in prion research. we here summarize the studies in which prion protein peptides have been used for immunization, to thus determine the most immunogenic parts of the prion protein.
COBISS.SI-ID: 25501145
The article describes the production of anti-idiotypic antibodies (Ab2) agains mAb V5B2, which selectively recognizes pathological isoform of PrP, PrPSc, in xenogeneic (hen) and syngeneic (BALB/c mice) experimental system. With adequate immunisation procedure following well-planned selection with mAbs, prepared in our laboratory in previous years, we were able not only to show that it was possible to produce Ab2, but also to use this approach in prion research.
COBISS.SI-ID: 2440072