The patent describes a simple way of production of anti-PrPSc monoclonal antibody (the majority of the project is based on this mAb) by using 13-amino acid long peptide from the primary structure of human PrP. BALB/c mice, expressing the whole PrP were used for the immunisation. After well-defined method of selection, a hybridoma cell line, producing IgG mAb was isolated.
F.21 Development of new health/diagnostic methods/procedures
COBISS.SI-ID: 17242073The research group Biomedicine (lead by prof. dr. V. Čurin Šerbec) is also engaged in the applicative project for the industrial partner (USA-France-Switzerland). Development of monoclonal antibodies for the new generation of blood grouping reagents is on the way. The experience od good practice from industrial projects is implemented in the research work of the group.
D.01 Chairing over/coordinating (international and national) projects
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