This publication reports mutations of FUS associated with amyotrophic lateral sclerosis (ALS). FUS is a nuclear protein, whose main known function is in metabolism of RNA (splicinng and expression of mRNA, miRNA biogenesis, etc.). This finding suggests the increasing importance of RNA metabolism in neurodegenerative diseases, especially as TDP-43, another ALS associated protein has simillar characteristics.
COBISS.SI-ID: 22877479
Invited talk given at the International Society for Neurochemistry meeting in Busan, South Korea 2009. The talk was based on the association of TDP-43 mutations with amyotrophic lateral sclerosis. Novel RNA binding properties of TDP-43 were discussed and related to neurodegenerative diseases such as ALS, fronto temporal dementia and Alzheimer's disease.
COBISS.SI-ID: 22913063