The proposed project is aimed at developing new drug candidates to prevent thrombosis. The task of the young researcher is developing ammodytase from the venom of the long-nosed viper (Vipera ammodytes ammodytes) towards pre-clinical and clinical studies. In addition, she is systematically analyzing repertoire of proteins from Vipera a. ammodytes venom for those components that interfere with haemostasis to discover new molecular tools to be used in blood testing and characterization.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 0000000Ammodytoxis (Atx) and basic subunit of crotoxin (CB), sPLA2s from snake venoms, are anticoagulant as well as neurotoxic. Anticoagulant effect results from binding of these sPLA2s to blood coagulation factor X (FXa), neurotoxicity may be related to binding to CaM. The aim of this project is to determine the 3D structure of complexes between Atx (and CB) and FXa or CaM as a starting point for designing of the synthetic peptides or peptidomimetics with anticoagulant and antineurotoxic effect to be used in clinics. Partner institution: Institut Pasteur, Pariz, Francija.
D.01 Chairing over/coordinating (international and national) projects
COBISS.SI-ID: 0000000In this project we will develop a new methodology to produce polyspecific antivenom towards the main toxic components of the long-nosed viper venom, of high and broad neutralising activity, to be used in efficient and safe treatment of envenomed patients and immunochemistry. The new procedure should not be variable in terms of quality of the product, should require low amount of venom and should have low if any side effects on antivenom-producing animals. We will tend to further improve the in vitro antivenom-quality-testing procedure. Partner: Institute of Immunology, Zagreb, Coatia.
D.01 Chairing over/coordinating (international and national) projects
COBISS.SI-ID: 0000000CIPKeBiP is connecting the top available expertise, knowhow, and technology of Slovenian research laboratories in protein science, thus emphasizing biomedical relevance of the applied project (priority health and life sciences). The Centre includes ten partner institutions from central and northeastern region of Slovenia, among them five industrial entities. We are focused on specific biological issues of high scientific relevance and of high biomedical (infectious diseases, signaling pathways) and environmental (adaption mechanisms of extremofiles) importance.
D.02 Establishment of a research centre, laboratory, study course, association
COBISS.SI-ID: 0000000The International Society on Toxinology was founded in 1962. The purpose of the Society is to advance knowledge on the properties of toxins and antitoxins and to bring together scholars interested in these substances through a common Society. The leading functions in the committees of European and international professional societies helps in the international recognition of Slovenian science and in strengthening of our national identity.
D.03 Membership in foreign/international boards/committees
COBISS.SI-ID: 0000000