In mammals, 29 enzymes with phospholipase A2 activity, which act intra- and/or extracellularly, have been identified. Most of the latter are secretory phospholipases A2. By their enzymatic activity or by binding to receptors, as ligands, sPLA2s play an important role in a variety of physiological and pathological processes. This has attracted the interest of pharmaceutical companies in developing sPLA2 inhibitors which could be helpful in sPLA2 related diseases, such as inflammation, atherosclerosis, neurodegeneration and cancer.
COBISS.SI-ID: 21552167