Our study showed the ability of astrocytes to synthesize neurotrophin-3 (NT-3) and that monoaminergic neurotransmitters noradrenaline, adrenaline, dopamine, but not serotonin, play an important role in the regulation of NT-3 production in neonatal rat cortical astrocytes. Downstream signaling responsible for the stimulation of NT-3 synthesis by monoamines involve the cAMP/protein kinase A pathway, activation of protein kinase C, and Ca2+ ions. These results explain interactions between neurotrophins and neurotransmitters in physiological and patophysiological conditions.
COBISS.SI-ID: 26449369
EDHF-mediated vasomotor response of the coronary artery is altered by hypoxia–reoxygenation (H–R) induced damage. This paper evaluates normothermic and hypothermic models which are suitable for future drug studies of vasoprotective action against H–R injury.
COBISS.SI-ID: 24825561