Brain-derived neurotrophic factor (BDNF) synthesis in astrocytes induced by noradrenaline is a receptor-mediated process utilizing two adrenergic pathways: beta1/beta2-adrenergic/cAMP and the novel alpha1-adrenergic/PKC pathway. BDNF is produced by astrocytes, in addition to neurons, and the noradrenergic system plays a role in controlling BDNF synthesis. We confirmed that the synthesis of astrocytic BDNF is an adaptable process using multiple types (alpha1 and beta1/beta2) of adrenergic receptor activation.
COBISS.SI-ID: 23055577
EDHF (endotelium derived hyperpolarising factor) is still unknown mediator of artery relaxation tat is important in degenerative processes as well in peripheral as well in coronary and cerebrovascular arteries. Our model was introduced for the purpose of evaluation of the protective mechanism of drugs during hypoxic and reoxygenation processes in proposed cardiovascular injuries.
COBISS.SI-ID: 24825561