Subjects with UGT1A1*28 genotype exhibited a twofold higher raloxifene exposure compared to hetero- and homozygotes for the wild-type allele. This indicates that raloxifene pharmacokinetics may be significantly affected by the UGT1A1*28 polymorphism. It was also demonstrated that *28 homozygotes gained a significantly greater increase in hip bone mineral density after 12 months of raloxifene treatment.
COBISS.SI-ID: 2510705
An enantioselective HPLC method with electrochemical detection was developed and validated for simultaneous determination of plasma concentrations of risperidone and 9-hydroxyrisperidone enantiomers. Following solid phase extraction the analytes were separated on AGP (?1 acid glycoprotein) column. Total analysis run time was 11 minutes. The method linearity was attained in the range from 1.0 to 100 ng/mL and the limit of detection was 0.5 ng/mL for all analytes. Method was successfully applied in a clinical study investigating the stereoselectivity of risperidone 9-hydroxylation.
COBISS.SI-ID: 2592369