In this work we have critically evaluated the role of lysosomes and lysosomal cathepsins in three major types of cell death, apoptosis, necrosis and autophagy, although the latter is probably not a cell death mechanism, but a survival one. The article is based also on our previous results.
COBISS.SI-ID: 22640935
TNF is a cytokine known to be an important mediator of apoptosis and inflammation in a number of diseases. TNF apoptosis has been known to be critically dependent on caspases; however, it has been recently suggested that cysteine cathepsins might also be involved in the pathway. Based on the use of caspase inhibitors, TNF-alpha induced caspase-dependent apoptosis, accompanied by lysosomal destabilization and the release of cathepsins in the cytosol. However, use of cathepsin inhibitors E-64d and CA-074 revealed that cysteine cathepsins only marginally affect the progression of apoptosis.
COBISS.SI-ID: 22717479