In the conference in which the leading researchers of multinational pharma companies were taking part the project leader has presented the results of fragment based discovery of novel inhibitors of DNA gyrase and their potential use as antimicrobilas. The lecture has raised considerable interest of the conference delegates.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4138010Our results on discovery of novel inhibitors of DNA gyrase using structure-based design and characterisation by biophysical methods were presented
B.03 Paper at an international scientific conference
COBISS.SI-ID: 2577777In the lecture we have revealed how the use of virtual screening based on cyclothialidine complex with DNA gyrase B enabled the discovery of novel analogs without lactone ring which renders the molecules pharmacokinetically unfavorable.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4174874Structure based virtual screening has resulted in a series of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles which showed interesting activity in experimentally determined inhibitory activity against DNA gyrase B.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4486170Structure based virtual screening of ATP binding site in the DNA gyrase B and the commercially available compounds database has resulted in a series of 2.4-dihydroxyphenylthiazoles as novel atp-ase inhibitors
B.03 Paper at an international scientific conference
COBISS.SI-ID: 4456986