The main clinical feature of dementia in Parkinosn's disease is a dysexecutive syndrome. This paper is a report from a pilot study with description of cognitive and imaging profiles in patients with mild to moderate stage of Parkinson's disease with dementia.
COBISS.SI-ID: 43554658
Othello syndrome (OS) is an organic delusional disorder with prevailing jealousy symptoms presumably appearing as side effect of antiparkinsonian therapy. The clinical spectrum of psychiatric symptoms in Parkinson's disease (PD) is very wide, including symptoms of depression and anxiety, hallucinations, delusions, with prevalent paranoid symptoms, agitation, delirium and sleep disorders. We report 5 patients with PD and OS.
COBISS.SI-ID: 26699481
Resting tremor is one of the four main clinical features of Parkinson's disease (PD). While rigidity, bradykinesia and postural instability can be explained with changes in neurotransmitter concentrations and neuronal activity in basal ganglia, the pathogenesis of parkinsonian tremor is not fully understood. In this article we discuss the possible mechanisms of tremor in PD.
COBISS.SI-ID: 26254809
Frst effective drugs for Parkinson's disease (PD) were the anticholinergics. Since the introduction of levodopa in the sixties of the previous century, many new drugs have emerged for the treatment of Parkinson's disease. In all stages of the disease, levodopa remains the most effective drug. However, long term treatment with levodopa is accompanied by the development of motor fluctuations and other neurological signs. Some of these drugs have caused considerable concern and controversies and were regarded at as the 'bad guys' of Parkinson's disease pharmacological armamentarium.
COBISS.SI-ID: 26254553
Several studies demonstrated alterations of gene expression in blood in various neurological disorders including Huntington's disease (HD). The aim of our study was to validate gene expression changes in a cohort of HD patients and evaluate their sensitivity and specificity. Four different groups were included: patients with HD, Parkinson's disease (PD), acute ischemic stroke (AS) and healthy controls. Gene expression changes in HD blood partly overlapped with those observed in blood from PD and AS patients. Predictive value for HD group was 78%, with 82% sensitivity and 53% specificity rate.
COBISS.SI-ID: 26255065