Mitochondrial transcription factor A (TFAM), B1 (TFB1M) and B2 (TFB2M) and mitochondrial RNA polymerase (POLRMT) form so-called mitochondrial DNA transcription machinery. We studied effect of this machinery on body fat deposition and fatty acid metabolism. Three mutations in TFAM, TFB1M and POLRMT were significantly associated with body fat deposition and fatty acids composition in beef cattle. Our results suggest that the basal mitochondrial transcription complex plays an important role in lipid metabolism and may be considered as candidate genes for obesity research in humans.
COBISS.SI-ID: 2372232
Random regression as previously developed for growth in bulls progeny tested was applied in pigs. Growth curve in Goettingen minipigs does not have a typical sigmoidal shape. Growth rate is slow and more or less uniform. Random regression did not model growth much better than simpler models. Similar results can be expected by other populations, expressing slow growth.
COBISS.SI-ID: 2245000