By using an equivalent electronic circuit either mitral or aortic regurgitation was simulated. Simulation allowed a measurement of various pressures and cardiac output, and also mitral and aortic flow. In normal conditions mitral and aortic flows were monophasic, anterograde. In valve regurgitation mitral and aortic flows were biphasic. The present investigation suggests that many features observed in patients with mitral or aortic regurgitation can be qualitatively satisfactorily simulated. In some respects even quantitative simulation is possible.
F.23 Development of new system-wide, normative and programme solutions, and methods
COBISS.SI-ID: 921695Antiphospholipid syndrome is the most common acquired hypercoagulation state of autoimmune disorder in children. Antiphospholipid antibodies were associated with various nonthrombotic clinical manifestations. Transplacentally transferred antibodies act as a risk factor, with possible neurodevelopmental changes. Data from the pediatric antiphospholipid syndrome studies have confirmed that antiphospholipid-antibody-related thromboses in children are frequently associated with multiple antiphospholipid antibodies positivity and concomitant presence of inherited prothrombotic disorders.
F.01 Acquisition of new practical knowledge, information and skills
COBISS.SI-ID: 24655065The EURODIAB study group prospectively registered data on the incidence of type 1 diabetes in childhood, calculated yearly incidences and trends in the increase in incidence. From the obtained results a trend prediction for the next 15 years was calculated for different regions in Europe.
F.16 Improvements to an existing information system/databases
COBISS.SI-ID: 26733785A review paper combines all latest state-of the-art knowledge on antiphospholipid syndrome in children, form intrauterine transplacental transfer to complications associated with vaccinations and viral infections. A majority of described entities was based on research conducted by the author in Slovenia, published in high impact scientific journals cited in the SCI.
F.15 Development of a new information system/databases
COBISS.SI-ID: 25581785Pump programming data from patients aged 0-18 years treated with CSII 16 European countries were recorded. HbA(1c) was measured centrally. A total of 1,041 patients participated. Glycemic control was better in preschool and pre-adolescent children than in adolescent patients. There was a significant negative correlation between HbA(1c) and daily bolus number. The use of <6.7 daily boluses was a significant predictor of an HbA(1c) level >7.5%. The incidence of severe hypoglycemia and ketoacidosis was 6.63 and 6.26 events per 100 patient-years, respectively.
F.01 Acquisition of new practical knowledge, information and skills
COBISS.SI-ID: 26733273