Validation of drug targets and subsequent preclinical studies are usually carried out on animal disease models, with mouse being the most commonly used. However, results from mouse models cannot always be directly related to human disease, such as observed with the compounds targeting cathepsins S and K. Therefore, we evaluated whether similar differences exist between murine and human cathepsin B. The expressed enzymes exhibited similar biochemical properties, indicating that cathepsin B transgenic mouse models could be useful for studying its role in human pathologies.
COBISS.SI-ID: 22472999