In this lecture we have presented optimisation of the methods for in vitro citrullination of proteins. In addition, we have shown how citrullination influences the degradation of gelatin (denatured collagen) and collagen) by cathepsins B, K, L and S, and various MMPs. Citrullinated gelatin was thus found to be degraded by various cathepsins almost 10-fold faster than noncitrullinated.
B.04 Guest lecture
COBISS.SI-ID: 22860583B. Turk is coordinator of the new FP7 project LIVIMODE, aimed at developing novel imaging tools based on protease activities for early diagnosis and monitoring of progression and treatment of diseases with focus on cancer and RA and OA. Project involves 10 partners from 5 countries and includes Sanofi Aventis as an industrial partner.
D.01 Chairing over/coordinating (international and national) projects
COBISS.SI-ID: 000000000Executive Editor is responsible for the quality of the articles published in the journal. Boris Turk is responsible for the field of proteolysis in this journal, which is the oldest in the field (formerly known as Biological Chemistry Hoppe-Seyler and other names) IF 2008 =3.035
C.04 Editorial board of an international magazine
COBISS.SI-ID: 1541908In the doctoral thesis a comprehensive overview of the role of cysteine cathepsins in inflammatory diseases is given, including their role in degradation of citrulinated proteins. An overview on citrulination and its importance is also presented.
D.09 Tutoring for postgraduate students
COBISS.SI-ID: 249942016In this work we have presented the status of research on cysteine cathepsins from synovial-like fibroblasts in arthritic diseases with the major focus on cathepsins B, L, S and K.
B.03 Paper at an international scientific conference
COBISS.SI-ID: 20911655