We present a method for lung cancer detection exploiting reflectance spectra measured in vivo during endoscopic imaging of the lung. The results demonstrated significant differences between the normal tissue/benign lesions and the malignant lesions in terms of tissue blood volume fraction, blood oxygen saturation, tissue scatterer volume fractions, and size distribution. The results also showed that the malignant lung lesions can be differentiated from normal tissue/benign lesions with both diagnostic sensitivity and specificity of better than 80%.
COBISS.SI-ID: 16965160
Fluorescence flexible bronchoscopy (FFB) has proved to be very useful for detecting carcinoma in situ and pre-cancerous lesions of the lung that are generally occult to white light reflectance bronchoscopy (WLRB). The increased sensitivity has caused a significant decrease of specificity, resulting in a large number of false positive signals that lead to a significant number of unnecessary biopsies. We have developed and have been testing a special system ClearVu Elite. There were differences found which are sufficiently pronounced to warrant initiation of a large, multicenter study.
COBISS.SI-ID: 19347743
We propose to combine field imaging endoscopy with point spectral analysis for improving the overall diagnostic accuracy in clinical lung cancer detection. For this purpose, we developed an integrated endoscopy system that uses autofluorescence imaging and white light reflectance imaging to obtain high diagnostic sensitivity, while at the same time uses non-contact point reflectance/fluorescence spectroscopy to reduce false positive biopsies, thus, achieve high diagnostic specificity, better than 80%.
COBISS.SI-ID: 19163943
To measure cell nuclei characteristics, previously reported to express probability for lung cancer, in subjects with different forms of pulmonary disease and those without disease. Sputum and buccal cell samples were obtained from 846 patients without pulmonary disease, with nonmalignant disease, COPD, asbestosis, lung cancer, stained for DNA, scanned by cytometer and scored. Results demonstrate that the DNA cellular characteristics on cytometry were more frequent among subjects with lung cancer but also among subjects with other pulmonary disease compared to subjects witbout pulmonary disease
COBISS.SI-ID: 18833822
Bolniki zrazličnimi pljučnimi boleznimi imajo zvišane vrednosti več označevalcev vnetja. V tej raziskavi smo skušali oceniti, ali bi bila določitev chitotriosidase v serumu koristna pri diagnozi in zdravljenju pljučnih bolezni. Rezultati so pokazali, da je aktivnost chitotriosidase povečana pri kroničnih vnetjih pljuč kot so sarkoidoza, azbestoza, pljučni rak.
COBISS.SI-ID: 16043259