Cristallographic evidence of kinetically predicted reaction intermediates. Fully occupied active site accommodates two substrate molecules while the active serine is acetylated. At oprimum activity, one sunstrate molecule is being hydrolyzed while the other one modulates the catalysis.
COBISS.SI-ID: 21911001
Warfarin is an anticoagulant drug with narrow therapeutic index and high inter-individual variability in dose requirement. We evaluated the effect of genetic and demographic factors on its metabolism and dose. CYP2C9 polymorphisms signifficantly influenced both parameters. Our findings were cited in Table 1 of the FDA approved updated Warfarin Prescribing Information of Bristol-Myers Squibb.
COBISS.SI-ID: 1729649
Invited review article putting forward predominantly our own data on the cell penetrating peptide carriers of useful compounds, like drugs. Peptides represent promising cell delivery vectors in vivo and in vitro.
COBISS.SI-ID: 18817753
We searched for genes that were differentially expressed in high saline environment and that were responsible for the adaptive mechanism. It was found that at high environmental osmolarity the halotolerant H.werneckii activates a different set of genes than other mesophylic yeasts. It was also revealed that MAP kinase in Hw-Hog1 pathway affects expression of several newly identified osmoresponsive genes.
COBISS.SI-ID: 23178969
Review article on the structural characteristics of inhibitors of human 17beta-HSD type1, involved in the estradiol synthesis and thus in the development of some hormone dependent diseases. As drugs, these inhibitors are used in therapy of endometriosis and ovarian or breast cancer. In the paper we summarized all known types of inhibitors and suggested lines for future research.
COBISS.SI-ID: 2232177