In order to optimize the surface display of recombinant proteins on L. lactis, we compared surface anchors from lactococci and phage endolysins. We were the first to describe a new type of surface anchor ChW from endolysin of lactococcal phage AM12, which exceeds the most established cAcmA anchor in terms of surface presentation efficiency.
COBISS.SI-ID: 32563239
We have prepared an overview of existing ways of using lactic acid bacteria to deliver therapeutic proteins, with special emphasis on applications aimed at treating cancer.
COBISS.SI-ID: 32035879
We discussed the safety and regulatory aspects of the use of genetically modified lactic acid bacteria and reviewed the approaches that are already used.
COBISS.SI-ID: 33217063