The aim of our prospective study was to evaluate the postoperative three-dimensional (3D) facial changes in skeletal Class III (SCIII) deformity in correlation with sagittal jaw movements. In 84 SCIII patients; one piece Le Fort I maxilla advancement only (N=18), set back of mandible only (N=38) or both procedures (N=28) were performed. At the time of pre- and post-operative (6 months after surgery) evaluations, all patients had fixed orthodontic appliances. Soft tissue changes were evaluated on optical 3D scans, whilst lateral cephalograms were superimposed to assess sagittal jaw movements. 3D facial surface scans were divided into 11 regions. We modelled soft tissue changes in each region by linear regression with maxillary (point A) and mandibulary (point B) sagittal movements as predictors, and additionally adjusted for sex, age, body mass index, operation type and interincisal angle. We found the highest values of regression coefficients for the sagittal movements of variables point A and point B within the regions of the upper and lower lips. These values were around 0.5, which meant that for each mm of maxillary advancement and mandibulary set-back, the soft tissue moved for 0.5mm. In side regions of the face the regression coefficients were between 0.1 and 0.3 and also occurred within regions indirectly affected by the operations.
COBISS.SI-ID: 4029612
Exposure to widespread lipophilic and bioaccumulative polychlorinated biphenyls (PCBs) induces diverse biochemical and toxicological responses in various organs, including the bone. The aim of this study was to evaluate the changes in growth rate, geometry, serum, and bone biochemical parameters and biomechanics of juvenile rat femur induced by lactational exposure to nonplanar PCB-155 and planar PCB-169 individually and in combination. Fifteen lactating Wistar rats were divided into four groups (PCB-169, PCB-155, PCB-155+169, and control), and PCBs were administered intraperitoneally at different time points after delivery. Femurs from 22-day-old offspring were analyzed by microCT, three-point bending test and inductively coupled plasma-mass spectrometry (ICP-MS) to obtain data on bone geometry, biomechanics and mineral composition. The serum levels of calcium, phosphate and alkaline phosphatase were also determined. Lactational exposure to planar PCB-169 resulted in shorter and thinner femurs, reduced endosteal and periosteal perimeters, smaller total cross-sectional and medullary areas, and lowered serum bone marker levels and calcium levels in the bone, while femur mechanical properties were not significantly altered. The changes observed in the combination exposure (PCB-155+169) group were similar to those observed in the PCB-169 group but were less pronounced. In summary, our results demonstrate that alterations in lactationally exposed offspring were primarily induced by planar PCB-169. The milder outcome in the combined group suggested that the PCB-169-mediated toxic effects on the bone might be reduced by a nonplanar PCB-155 congener.
COBISS.SI-ID: 4170618
The fracture resistance of glazed four-unit posterior dental bridges after mechanical fatigue testing and artificial ageing was evaluated. Thirty identical monolithic bridges were fabricated from "translucent" zirconia and divided into three groups of ten. The first group was monotonically loaded to fracture; the second group was dynamically loaded in water (0-300 N, 10[sup]6 cycles) prior to fracture, while the third group was first subjected to accelerated ageing (in a diluted acetic acid solution at 134°C for 12 h), then to mechanical fatigue and finally monotonically loaded to fracture. Two tested bridges did not survive 106 cycles of dynamic loading, one in Group 2 and one in Group 3. Mean monotonic fracture loads (N) were:Group 1: 547.3 +- 66.3, Group 2 (n = 9): 465.2 +- 118.0, and Group 3 (n = 9): 408.8 +- 58.9. According to the fractographic analysis the glaze embrittlement during artificial ageing and the stress corrosion during fatigue loading are proposed to be responsible for the reduced fracture resistance.
COBISS.SI-ID: 33220057
Background and objective: Periodontal disease is one of common oral manifestations in patients with Fanconi anemia (FA). The aim of the study was to evaluate the effect of photodynamic therapy (PDT) on periodontal clinical and microbial parameters in a patient with FA. Materials and methods: For a 16-year-old girl, diagnosed with having FA and periodontal disease, the protocol treatment with duration of 10 months was designed. Every 2 months, thorough oral cavity disinfection was followed by PDT, using photosensitizer phenothiazine chloride activated by a diode laser light. During each visit, periodontal parameters were evaluated: plaque index (PI), gingival index (GI), probing pocket depth (PPD), bleeding on probing (BOP), and clinical attachment level. Simultaneously, the presence of Candida albicans and of five periodontal pathogens was evaluated. Results: Clinical results showed improvement in GI, BOP, and PPD during this 10-month period. BOP subsequently reduced from 100% to 79%, 72%, and 60% at 6, 8, and 10 months, respectively. The proportion of sites with PPD of )-4mm decreased from 38.7% at the baseline to zero after 10 months. Further, all five bacterial species and C. albicans were reduced significantly. Conclusions: PDT effectively influences periodontal healing and reduces periodontopathogenic bacteria without damaging the patient's tissues.
COBISS.SI-ID: 32841433
The aim of this cross-sectional study was to investigate the oral health and serum biomarkers among the hemodialysis (HD) patients in Slovenia. 111 HD patients were periodontally examined and their sera were assayed for C-reactive protein (CRP), cardiac troponin T (TnT), nitrite/nitrate (NOx) and antibody levels to A. actinomycetemcomitans and P. gingivalis. The association of oral health with systemic response was analyzed with Kruskal-Wallis test, Fisher’s exact test and multivariate linear regression. Bleeding on probing without periodontal pockets was present in 5.2%, calculus without periodontal pockets in 42.1%, shallow periodontal pockets in 39.5% and deep periodontal pockets in 13.2% of dentate patients. There were 28.8% edentulous participants. 63.1% of the patients had CRP levels higher than 3 mg/L and 34.2% higher than 10 mg/L. TnT was detectable in all participants, with 25.2% exhibiting levels higher than 100 ng/L. The median level of NOx was 43.1 μmol/L. Participants with higher CRP were more likely to be edentulous and have higher TnT levels. A direct association of oral health with TnT or NOx was not detected.
COBISS.SI-ID: 4336250