Electroporation-based therapies such as electrochemotherapy (ECT) and irreversible electroporation (IRE) are emerging as promising tools for treatment of tumors. When applied to the brain, electroporation can also induce transient blood-brain-barrier (BBB) disruption in volumes extending beyond IRE, thus enabling efficient drug penetration. The main objective of this study was to develop a statistical model predicting cell death and BBB disruption induced by electroporation.
COBISS.SI-ID: 11290452
The paper presents the results of a clinical trial of electrochemotherapy for the treatment of hepatocellular carcinoma. The study included 10 patients with 17 tumors. Complete response was obtained after 3-6 months follow-up in 80 % of the treated patients and 88 % of the treated tumors.
COBISS.SI-ID: 11965780
The paper presents a validated model for treatment planning irreversible electroporation treatments of malignant gliomas. The model was prepared based on a study on 7 canine patients and enables the prediction of probability of cell death based on the electric field strength and the number of deliverd electroporation pulses.
COBISS.SI-ID: 11788116