Projects / Programmes
Sinteze in transformacije organskih spojin. Novi reagenti v organski sintezi. Stereoselektivne in regioselektivne sinteze aminokislin, (Slovene)
Code |
Science |
Field |
Subfield |
1.04.04 |
Natural sciences and mathematics |
Chemistry |
Organic chemistry |
Code |
Science |
Field |
P390 |
Natural sciences and mathematics |
Organic chemistry |
organic chemistry, heterocyclic chemistry, 1,3-dipolar cycloadditions, stereoselective synthesis, regioselective synthesis, 2,2-disubstituted ethenylamino-3-dimethylaminopropenoates, 2-acylamino-3-cyanopropenoates, C-nucleosides, heterocyclic polyols, chiral azomethine imines.
Researchers (12)
Organisations (1)
Abstract
This research project is dealing with: the syntheses and transformations of 2,2-disubstituted ethenylamino-3-dimethylaminopropenoates , 2-acylamino-3-cyanopropenoates and realted compounds as versatile reagents for the preparation of various heterocyclic systems, such as furans, pyrrols, pyrazoles, imidazoles, piridines, pyridazines, pyrimidines and their fused analogs. The intention is the development of general methods and reagents, selectivity and regioselectivity of chiral dimethylaminopropenoates, azomethine imines and analogs as building blocks in the synthesis of complex chiral molecules. We can introduce with them also a protected amino or hydroxy group, since the protecting group can be easily removed. They open an easy access to several natural products, such as aplysinopsins and azaaplysinopsins.
The syntheses of chiral heterocyclic compounds are dealing with the syntheses and transformations of heteroarilalanines, C-nucleosides and polyhydroxy heterocyclic systems, pyrazolo/1,2-a/pyrazoles and stereoselective 1,3-dipolar cycloadditions of diazolakanes, nitril oxides, nitril imines and azomethine imines to unsaturated and heterocyclic systems.