Projects / Programmes
Neuroprotective treatment after hypoxic-ischemic brain injury in the neonatal period
| Code |
Science |
Field |
Subfield |
| 3.03.00 |
Medical sciences |
Neurobiology |
|
| Code |
Science |
Field |
| B640 |
Biomedical sciences |
Neurology, neuropsychology, neurophysiology |
neuroprotection, hypoxic-ischemic injury, brain, neonatology
Researchers (1)
| no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
| 1. |
21413 |
PhD Damjan Osredkar |
Human reproduction |
Head |
2007 - 2008 |
485 |
Organisations (1)
Abstract
Hypoxic-ischemic brain injury affects approximately 1-4/100 full term newborns. The survivors often experience severe neurological conditions, such as cerebral palsy, epilepsy, mental retardation, etc. Previous research suggests the possibility that brain injury may be amenable to post-natal neuroprotective interventions.
In the proposed research project, based on animal experiments, we would like to further investigate the effectiveness of neuroprotective treatment with 2-iminobiotin, erythropoietin, hypothermia and other drugs / therapies. We are interested in treatment with single drug / therapy as well as in protocols that would combine several neuroprotective strategies. We are particularly interested in those aspects of neuroprotection that might be applicable to treatment of human newborns.
Significance for science
Neuroprotective treatment of neonates with hypoxic-ischemic brain injury are relatively new approach. First concrete evidence of benefits of treatment with induced hypothermia were published in 2005. Many other potentially beneficial therapeutic approaches are not yet in clinical use. The results of our study support the use of hormone erythropoietin for neuroprotective treatment of neonates with hypoxic-ischemic brain injury and so represent an important contribution to the knowledge and conception of new therapeutic approachs. Th results of our study elucidate until now unstudied field o the role of erythropoietin in neurogenesis in hippocampus, which is often damaged in hypoxic-ischemic injury of brain in neonatal period and is at the same time of vital importance for memory in human.
Significance for the country
Induced hypothermia is used for treatment of newborns with hypoxic-ischemic brain injury in Slovenia since 2006. Many potential neuroprotective treatments are being investigated, but they are not yet in clinical use, such as treatment with hormone erythropoietin. The results of our study support the use of erythropoietin in neuroprotective treatment of newborns. The knowledge gained through this study allows us to further study its role in Slovene laboratories and so help mold the future neuroprotective approaches and help them translate into clinical practice to help improve the health of our kids. Withe dissemination of our knowledge not only in the international and Slovene scientific circles, but also in the lay public we have helped with promotion of neuroprotective treatment as well as science per se.
Most important scientific results
Final report,
complete report on dLib.si
Most important socioeconomically and culturally relevant results
Final report,
complete report on dLib.si
