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Projects / Programmes source: ARIS

Molecular structure and dynamics in relation to biological activity of vancomycin type antibiotics

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Research activity

Code Science Field Subfield
1.04.02  Natural sciences and mathematics  Chemistry  Structural chemistry 

Code Science Field
P351  Natural sciences and mathematics  Structure chemistry 
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (1)
no. Code Name and surname Research area Role Period No. of publications
1.  08329  PhD Simona Golič Grdadolnik  Chemistry  Head  1998 - 2001  0 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  10 
Abstract
The structure and dynamics of vancomycin family of antibiotics and their complexes with cell wall precursors is investigated by NMR spectroscopy and restrained molecular dynamics simulations. The detailed knowledge of binding interactions, which can be obtained from such studies would allow design of novel biologically active substances based on vancomycin, which is important for clinical treatment of life-threatening Gram-positive bacterial infections. The understanding of exact mechanism of action of these antibiotics will explain also the function and activity of variety of other complex biological systems.
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