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Projects / Programmes source: ARIS

Numerical modeling of tissue electroporation for electrochemotherapy

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Research activity

Code Science Field Subfield
2.06.07  Engineering sciences and technologies  Systems and cybernetics  Biomedical technics 

Code Science Field
T115  Technological sciences  Medical technology 
Keywords
electroporation, electrochemotherapy, numerical modeling, finite elements method
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (4)
no. Code Name and surname Research area Role Period No. of publications
1.  12537  PhD Alenka Maček - Lebar  Systems and cybernetics  Head  2002 - 2004  224 
2.  10268  PhD Damijan Miklavčič  Systems and cybernetics  Researcher  2002 - 2004  1,518 
3.  20822  PhD Nataša Pavšelj  Systems and cybernetics  Researcher  2002 - 2004  82 
4.  19709  MSc Blaž Podobnik  Medical sciences  Researcher  2002 - 2004  10 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  28,171 
Abstract
Electroporation is a process, which causes transient high-permeability of the cell membrane due to application of electric field. In the state of high-permeability, membrane allows different small and large molecules to be introduced into the cytoplasm, although cell plasma membrane represents a formidable barrier for them in its normal state. Electroporation is a phenomenon which is already widely used in biotechnology, cell biology and its importance in clinical practice is growing. Therapy which uses electric pulses to potentiate cytotoxic drug delivery to tumor cells is named electrochemotherapy. Electroporation is also one of the most widely used methods for introducing DNA into cells in vitro. The aim of electrotransfection in vivo is gene therapy. Calculation of electric field distribution during electropermeabilization in vivo is a new tool for evaluation of the phenomena. The main purpose of this project is to evaluate the influence of electric currents and voltages as well as geometry and position of the electrodes on the efficiency of the electroporation in vivo for electrochemotherapy and gene transfection. Till now methematical models in this field described only quasi-stationary electric field in the chosen tissue. But electric conductivity of the tissue, which is electroporated, is changed. In the project proposed we will take into account this changes. The final aim of this project is to adapt the therapy for the patient, i.e. to choose the shape and position of the electrodes as well as the voltage amplitude with respect to electric field distribution in the tissue which has to be treated. Electric field intensity through the tissue should be above threshold value needed for effective permeabilization and lower than the value that causes irreversible tissue injury.
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