Projects / Programmes
Genetic and environmental risk factors for bone remodelation disturbances
Code |
Science |
Field |
Subfield |
1.09.00 |
Natural sciences and mathematics |
Pharmacy |
|
Code |
Science |
Field |
B580 |
Biomedical sciences |
Skeleton, muscle system, rheumatology locomotion |
osteoporosis, estrogen receptor, tartrate resistant acinaphosphatase, bone alkaline phosphatase
Researchers (8)
Organisations (1)
Abstract
Osteoporosis is a multifactorial bone disease influenced by genetic an environmental factors (physical activity, diet). The connection between decreased bone mineral density (main symptom of the osteoporosis) and the treatment effect on one hand and the presence of genetic modifications (mutations) in the genes for estrogenic receptor alpha and beta and gene for cathepsin K will be studied. For this purpose, the coding regions of the three genes will be examined for the presence of genetic modifications, and protocols for their routine determination in patients will be developed.Medicinal plants and plant derived food will be screened for the presence of inhibitors of two enzymes: 1) bone alkaline phosphatase, which is involved in bone formation and 2) tartrat resistant acid phosphatase, which is involved in bone resorption. The inhibitors of the first enzyme could accelerate the osteoporosis process and people from the risk groups should avoid such food. The inhibitors of the second enzyme could be slow down the disease process and could lead to the development of new drugs against osteoporosis.