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Projects / Programmes source: ARIS

T lymphocytes, immune complexes and leukotrienes in patogenesis of chronic urticaria

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Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B500  Biomedical sciences  Immunology, serology, transplantation 
Keywords
chronic urticaria, T lymphocytes, immune deposites, leukotrienes
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (3)
no. Code Name and surname Research area Role Period No. of publications
1.  15781  Izidor Kern  Oncology  Researcher  2002 - 2004  0 
2.  10921  PhD Mitja Košnik  Microbiology and immunology  Head  2002 - 2004  0 
3.  00288  PhD Ema Mušič  Microbiology and immunology  Researcher  2002 - 2004  0 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  1613  University Clinic of Respiratory and Allergic Diseases  Golnik  1190997  0 
Abstract
Chronic urticaria is an unpleasant diseases which is not accesible for ethiologic treatment. According to prominent mast cell and eosinophil infiltrate a prominent role of sulphidoleukotriens in the pathogenesis of chronic urticaria is expected and a role of antileukotriene drugs might become impotrant. 30 adult patients with chronic urticaria and poor response to systemicantihistamines would be additionally double blind crossover treated with antileukotriene montelucast 10 mg. The area of involved skin and itching would be followed. Activation of lymphocyte subpopulation, their cytokine profile, appearance and characteristics of immune deposites will be studied in 3 mm skin punch biopsies.
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