Projects / Programmes
Biologija tumorjev (Slovene)
January 1, 1999
- December 31, 2003
| Code |
Science |
Field |
Subfield |
| 3.04.00 |
Medical sciences |
Oncology |
|
| 3.07.00 |
Medical sciences |
Metabolic and hormonal disorders |
|
| 1.05.00 |
Natural sciences and mathematics |
Biochemistry and molecular biology |
|
| Code |
Science |
Field |
| B200 |
Biomedical sciences |
Cytology, oncology, cancerology |
| B211 |
Biomedical sciences |
B211 |
| B480 |
Biomedical sciences |
Endocrinology, secreting systems, diabetology |
| B520 |
Biomedical sciences |
General pathology, pathological anatomy |
| B340 |
Biomedical sciences |
Animal anatomy, animal morphology |
| P170 |
Natural sciences and mathematics |
Computer science, numerical analysis, systems, control |
.
Researchers (7)
Organisations (1)
Abstract
One of the definitions of the tumour process is, that a tumour is enlargement of the cell population. The size of the cell population depends from the balance between cell proliferation and cell death (apoptosis). The balance between them is the basis for the maintenance of the human body homeostasis. If it is destroyed, whether the cells uncontrolled proliferate or the apoptosis decreases, the cell proliferation increases until the tumour is formed. The theory of cancerogenesis about more hits is generally accepted today. After this theory the predomination of the most malignant cell clones in tumour is going on. Understanding of the genetic mechanisms, that regulate the cell cycle and apoptosis in the normal as well as malignant cell, represents the basis for the understanding of the carcenogenetic processes. It is especially important to study thoroughly the proliferation and apoptotic mechanisms in those lesions, that will bring the malignant alterations. With the knowledge of these alterations we could avoid serious consequences of the cancer disease. By the assessment of the cell size proliferation the proliferation markers PCNA, MIB and Ag-NOR are especially important, while the process of apoptosis can be studied on light microscopical level with the ISEL or TUNEL method. In the proposed research programme the process of the cancerogenesis will be studied with the tumour proliferation and apoptotic markers. The importance will be given to the thyroid gland, which will be studied in "in vitro" as well as "in vivo" conditions. The FRTL-5 cell line will be studied in a cancerogenetic model and the experiments "in vivo" on the consanguine animals will be performed. The thyroid carcerogenesis is especially interesting because of the incidence of the thyroid tumours increase with the use of the nuclear energy and by the nuclear catastrophes. We will be especially interesting in the goitre precancerotic lesions. We would like to find out, if the model of the multistage transformation process is valid also for the thyroid cancerogenesis. Besides thyroid tumours, the tumours of some other organic systems will be studied especially those that show the highest world incidence such as prostatic gland, larynx and liver. The human tumours will be the most interested. With the help of the above mentioned markers the answers on the diagnostic questions and correlation between tumour markers and survivals as well as of the recurrence complaint will be given. We are interesting in those cell changes that allow transition from one tumour phase to the next. The most important quastions are the transitions of the precancerosis to the malignant tumour, from the in situ formation to the real invasive carcinoma and transition from the invasive process without metastasis to the metastatic tumour formation. As the cancer is indubitably genetic illness, we will be interested in how the genes effect on the mentioned tumours, what kind of co-operation between oncogens as well as suppresser genes in the proliferation and apoptotic regulation mechanisms take place. Understanding of the cancerogenesis will give us some new information about tumours and facilitate the decisions about the optimal and timely therapy for the cancer diseases.
Most important scientific results
Final report
Most important socioeconomically and culturally relevant results
Final report
