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Projects / Programmes source: ARIS

Engineering of future innovative and smart hybrid materials by combining laser-functionalized metals and living cells (LaserInSMArT)

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Research activity

Code Science Field Subfield
2.10.00  Engineering sciences and technologies  Manufacturing technologies and systems   

Code Science Field
2.03  Engineering and Technology  Mechanical engineering 
Keywords
laser ablation, surface engineering, laser-material processing, surface functionalization, biocompatible materials
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Points
8,179.89
A''
2,030.54
A'
4,362.45
A1/2
6,028.9
CI10
8,646
CImax
306
h10
45
A1
30.08
A3
14.38
Data for the last 5 years (citations for the last 10 years) on June 28, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Database Linked records Citations Pure citations Average pure citations
WoS  468  10,261  8,688  18.56 
Scopus  494  11,731  10,012  20.27 
Researchers (14)
no. Code Name and surname Research area Role Period No. of publications
1.  25126  PhD Črtomir Donik  Materials science and technology  Researcher  2021 - 2024  0 
2.  11155  PhD Damjana Drobne  Biology  Researcher  2021 - 2024  0 
3.  29224  PhD Peter Gregorčič  Manufacturing technologies and systems  Head  2021 - 2024  0 
4.  32545  PhD Matej Hočevar  Materials science and technology  Researcher  2021 - 2024  0 
5.  50212  PhD Luka Hribar  Manufacturing technologies and systems  Researcher  2022 - 2024  0 
6.  21238  PhD Matija Jezeršek  Manufacturing technologies and systems  Researcher  2021  0 
7.  18475  PhD Aleksandra Kocijan  Materials science and technology  Researcher  2021 - 2024  0 
8.  35369  PhD Veno Kononenko  Biochemistry and molecular biology  Researcher  2022 - 2024  0 
9.  38896  PhD Matjaž Kos  Manufacturing technologies and systems  Researcher  2021 - 2024  0 
10.  54319  PhD Eva Kranjc  Control and care of the environment  Researcher  2021 - 2024  0 
11.  33175  PhD Sara Novak  Biology  Researcher  2021 - 2024  0 
12.  27773  PhD Ivan Sedmak  Process engineering  Researcher  2022 - 2024  0 
13.  52342  Matej Senegačnik  Manufacturing technologies and systems  Technical associate  2021 - 2023  0 
14.  36685  PhD Matevž Zupančič  Process engineering  Researcher  2021 - 2024  0 
Organisations (3)
no. Code Research organisation City Registration number No. of publications
1.  0782  University of Ljubljana, Faculty of Mechanical Engineering  Ljubljana  1627031  0 
2.  0206  Institute of Metals and Technology  Ljubljana  5051622000  0 
3.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  11 
Abstract
Development of new biomaterials is of great importance for patients and has significant impact on European healthcare. Currently, the biomedical field relies on the use of non-smart biomaterials that are based on the traditional categories of polymers, metals, ceramics, and their composites. They suffer limitations resulting in lack of biospecificity (e.g., biosensing) and reduced longevity that is important for medical implants. To develop new biomimetic and bioresponsive biomaterials, and thereby fill this gap, a deep understanding of tissue/cell-biomaterial interaction is still needed. LaserInSMArT will clarify how the surface chemistry and topography influence the interaction between the surface and biological cells. This we will achieve by developing of smart, specifically tailored hybrid materials, which will be comprised of a combination of functionalized metallic surfaces and living cells. We will engineer the hybrid materials with the goal of combining bulk metals with desired mechanical properties and the autonomous, adaptive, and self-healing characteristics of living organisms. In this way, the developed materials will be able to detect external signals and respond via remodelling, implement patterning across different length scales, and organize inorganic compounds to create biotic-abiotic composites. We will seek the inspiration for developing hybrids in natural biological systems, such as biofilms, skeletal tissues, and shells, which exhibit great examples of combining non-living and living components. LaserInSMArT will use laser material engineering that we have developed within our previous research projects (Z2-9215; J2-7196; J2-1741; and J2-1729). By using a flexible, scalable and chemical–free additive manufacturing process, we will produce three-dimensional (3D) shapes with appropriate porous structure from conventional metals. These metal alloys will be (i) non-toxic; (ii) easy to recycle to ensure sustainability; and (iii) exhibiting appropriate mechanical properties. We will start with conventional metals/metal alloys (stainless steel, Ti, FeMn and Mg) that are already widely used in biomedical applications because of their favorable properties, including high strength, good fracture resistance, electrical conductivity and formability. However, these materials offer only limited options for interaction with biological cells – a functionality which is important in the development of hybrid materials. A variety of cellular functions, such as adhesion, proliferation, and differentiation importantly depend on surface interaction at the cell–biomaterial interface. Thus, the surfaces of 3D samples will be further functionalized using laser texturing that has been proven as one of the most promising paramount methods in this field. Results of the study about interaction between the functionalized surfaces and the cells will enable us to tailor specific patterns of biological cells (e.g., osteoblast, stem, and endothelial cells) on the functionalized metallic surfaces. Furthermore, they will enable to study how these patterns grow in a laboratory environment. The project results will allow us to tailor smart hybrid materials that will improve the biocompatibility of medical implants and will be able to emulate the natural systems. The developed approaches for the fabrication of smart hybrids will open new possibilities for research of interactions between surfaces and living microorganisms, light, other electromagnetic fields, molecules and atoms.
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