Projects / Programmes
New startegies for fabrication of biomimetic vascular implants
Code |
Science |
Field |
Subfield |
3.06.00 |
Medical sciences |
Cardiovascular system |
|
Code |
Science |
Field |
3.02 |
Medical and Health Sciences |
Clinical medicine |
nanostructure, biomimetic surface, hemocompatibility, biocompatibility, vascular stent, titanium alloy, surface treatment, gaseous plasma
Researchers (18)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
34541 |
PhD Metka Benčina |
Materials science and technology |
Researcher |
2020 - 2023 |
81 |
2. |
52566 |
PhD Darja Božič |
Biotechnology |
Researcher |
2020 |
67 |
3. |
53529 |
Jernej Ekar |
Electronic components and technologies |
Junior researcher |
2020 - 2023 |
48 |
4. |
04634 |
PhD Aleš Iglič |
Systems and cybernetics |
Researcher |
2020 - 2023 |
978 |
5. |
28480 |
PhD Ita Junkar |
Medical sciences |
Head |
2020 - 2023 |
289 |
6. |
15703 |
PhD Janez Kovač |
Electronic components and technologies |
Researcher |
2020 - 2023 |
693 |
7. |
28845 |
PhD Katja Lakota |
Microbiology and immunology |
Researcher |
2020 - 2023 |
248 |
8. |
36461 |
PhD Luka Mesarec |
Physics |
Researcher |
2020 - 2023 |
64 |
9. |
28467 |
PhD Samo Penič |
Electronic components and technologies |
Researcher |
2022 - 2023 |
120 |
10. |
33326 |
PhD Gregor Primc |
Electronic components and technologies |
Researcher |
2020 - 2023 |
278 |
11. |
53323 |
Anna Romolo |
|
Technical associate |
2022 - 2023 |
46 |
12. |
53463 |
PhD Pia Starič |
Medical sciences |
Junior researcher |
2020 - 2023 |
53 |
13. |
57380 |
PhD Szymon Starzonek |
Systems and cybernetics |
Researcher |
2023 |
37 |
14. |
13601 |
PhD Matija Tomšič |
Microbiology and immunology |
Researcher |
2020 - 2023 |
767 |
15. |
17622 |
Janez Trtnik |
|
Technical associate |
2020 - 2023 |
18 |
16. |
20048 |
PhD Alenka Vesel |
Electronic components and technologies |
Researcher |
2020 - 2023 |
706 |
17. |
34203 |
PhD Ekaterina Yurieva Gongadze |
Neurobiology |
Researcher |
2020 - 2023 |
73 |
18. |
24206 |
PhD Polona Žigon |
Microbiology and immunology |
Researcher |
2020 - 2023 |
178 |
Organisations (3)
Abstract
New startegies for fabrication of biomimetic vascular implants Cardiovascular diseases cause millions of deaths all over the world and present a serious health care burden. The minimally invasive way to treat diseased blood vessels is by insertion of expandable tubular stent. Vascular stents have already saved countless lives, but unfortunately their surface properties are still far from optimal. Hence, many research efforts have been directed in optimizing its surface performance. Thus various coating strategies have been developed in order to improve surface properties of so called bare metal stents (BMS) and the new generation of drug eluting stents (DES) was born. The main driving force was to supress rapid smooth muscle cell (SMC) proliferation, which is connected with narrowing of vessel wall (restenosis occurs in 30-50%). It soon became evident that DES could not fully solve this issues, as coatings indeed inhibited growth of SMCs but regrettably growth of ECs was also supressed which increased the risk of thrombosis. Since then various attempts have been made in order to improve surface performance of vascular stents, but unfortunately only incremental improvements were made. The aforementioned issues clearly show that novel surface treatment strategies should be sought. Thus the aim of proposed project directs this issue in particular, as novel approaches for surface treatment are proposed based on biomimetic surfaces, which are inspired from nature and will be fabricated by combination of novel surface treatment techniques; gaseous plasma treatment, hydrothermal treatment and novel plasma anodization method where atmospheric plasma jet will be employed. The first two approaches will be used in combination, while plasma anodization process is novel approach and could be used alone or in combination with gaseous plasma treatment. The main goal is to obtain nanostructured surfaces, which provide guidance to cells and could favour growth of one cell type over another. Surface treatment by highly reactive plasma will be used in order to optimise formation of high quality titanium oxide layers in order to improve biological response and corrosion resistance. The main objectives of the project are: i.) Fabrication of nanostructured-biomimetic surfaces (hydrothermal treatment (HT)) followed by surface chemical modification by low pressure plasma treatment. ii.) Surface modification by low pressure plasma treatment followed by fabrication of nanostructured – biomimetic surfaces (hydrothermal treatment (HT) or plasma anodization). Plasma electrolysis, as a novel approach, will be studied as one step process as it could enable both nanostructuring and surface modification simultaneously. iii.) Optimizing parameters for fabrication of nanostructured-biomimetic surfaces in terms of optimal treatment procedures and treatment conditions used in order to gain desired nanotopography, mechanical stability, corrosion resistance and biological response. iv.) Evaluating different approaches; their variations in nanotopographies and chemistries on the in vitro biological response with SMCs, ECs and whole blood as well as possible commercial use of optimal treatment approach.