Projects / Programmes
Activity of the uterine smooth muscles in pregnancy and during labour
| Code |
Science |
Field |
Subfield |
| 3.05.00 |
Medical sciences |
Human reproduction |
|
| Code |
Science |
Field |
| B570 |
Biomedical sciences |
Obstetrics, gynaecology, andrology, reproduction, sexuality |
| B470 |
Biomedical sciences |
Physiology |
Uterus, uterine corpus, electromyography
Researchers (20)
Organisations (2)
Abstract
For normal functioning of the uterus during pregnancy and labour it is essential that the activity (relaxation, contraction) of the myometrium in the uterine corpus and cervix collaborate closely. Every single dysfunction in this relationship may lead to serious perinatal complications, such as preterm or prolonged labour, and may even cause perinatal morbidity and neonatal mortality. The activity and the role of the cervical smooth muscles have not been thoroughly investigated. The objective of this research is to find how the bundles and layers of smooth muscles in the cervix and uterine corpus, following the longitudinal and circular pattern, contract and relax under various conditions: in differently ripe cervices and in different phases of labour.
Project Design: It consists of four (A,B,C,D) interrelated studies.
Method: measurements, mathematical and statistical analyses of electrical activity of the smooth muscles in the cervix and uterine corpus in human and ewes. The analysis will involve the data on mechanical activity of the cervix (dilatation) and uterine corpus (intrauterine pressure).
We wish to contribute to the knowledge of the nature of contractions of the smooth muscles in the cervix and uterine corpus in preterm labour, at the transition from pregnancy to labour, in the course of labour, and how these factors affect cervical dilatation. Thus we will be able to implement the policy of more economical and efficient use of certain drugs in case of complications.
