Projects / Programmes
Elastazni alfa-1 proteinazni inhibitor, hipofosfatemija in citokini v zgodnji diagnostiki sepse novorojenčka (Slovene)
Code |
Science |
Field |
Subfield |
3.05.00 |
Medical sciences |
Human reproduction |
|
Code |
Science |
Field |
B660 |
Biomedical sciences |
Pediatrics |
B590 |
Biomedical sciences |
Anaesthesiology, intensive care |
Elastase alpha-1 proteinase inhibitor, hypophosphataemia, intracellular ATP, 2,3 DPG, IL-6, soluble receptors for IL-2, IL-8, procalcitonin, newborn, severe infection
Researchers (11)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
05273 |
PhD Janez Babnik |
Human reproduction |
Researcher |
1996 - 2001 |
180 |
2. |
02148 |
PhD Metka Derganc |
Human reproduction |
Head |
1996 - 2001 |
454 |
3. |
06756 |
PhD Štefan Grosek |
Human reproduction |
Researcher |
1996 - 2001 |
642 |
4. |
01521 |
PhD Marija Gubina |
Microbiology and immunology |
Researcher |
1999 - 2001 |
370 |
5. |
12445 |
MSc Gorazd Kalan |
Human reproduction |
Researcher |
1999 - 2001 |
121 |
6. |
07792 |
Inka Lazar |
Human reproduction |
Researcher |
1996 - 2001 |
56 |
7. |
10691 |
PhD Joško Osredkar |
Human reproduction |
Researcher |
1999 - 2001 |
1,318 |
8. |
02179 |
PhD Janez Primožič |
Human reproduction |
Researcher |
1996 - 2001 |
273 |
9. |
15443 |
MSc Alenka Sešek Briški |
Metabolic and hormonal disorders |
Researcher |
1996 - 2001 |
103 |
10. |
07793 |
Ivan Vidmar |
Human reproduction |
Researcher |
1998 - 2001 |
249 |
11. |
04890 |
PhD Branka Wraber |
Microbiology and immunology |
Researcher |
1999 - 2001 |
266 |
Organisations (2)
Abstract
In the project, diagnostic value of elastase alpha-1 proteinase inhibitor (E-A1PI), hypophosphataemia, intracellular adenosine triphoshate (ATP) and 2,3 diphoshoglycerate (2,3 DPG), cytokines IL-6 and soluble receptors for IL-2 for the early diagnosis of severe neonatal infection was studied and compared with routinely used laboratory tests C-reactive protein (CRP) and leukocyte count and differential. In the study of 58 critically ill newborns, presented as magisterial thesis, E-A1PI proved to be a more sensitive marker of infection than CRP , leukocyte count and differential ( E-A1PI sensitivity 82 %, vs. CRP 40% and % bands 38%), and increased to 94 % at second determination. In the second study of 46 critically ill newborns (magisterial thesis) IL-6 was also a more sensitive (sensit. 92.8%) marker of infection than CRP (sensit. 85%). Soluble receptors for IL-2, however, were less sensitive (71%) but more specific (63% vs. CRP 40%). The area under the curve in ROC analysis for IL-6 was 0.794, for CRP 0.765 and soluble receptors for IL-2 0.732. Hypophosphataemia was significantly more common in severe infection than in hyaline membrane disease (HMD) and was due to the increased urine excretion. In severe infection significantly lower concentration of intracellular ATP and higher compensatory intracellular 2,3 DPG was found in comparison with hyaline membrane disease. A pilot study of IL-8 and procalcitonin has begun indicating their clinical usefulness.