Presynaptically toxic phospholipases a2, research tools in neurobiology

Code

J3-7888 (D) - included in ARIS records

Head

PhD Franc Gubenšek

Period

1/1/1996 - 6/30/2001

Science

Natural sciences and mathematics (7)

Reseacher status

Researcher (7)
Junior expert or technical associate (0)

Education

Doctor's degree (7)

Sex

Woman (2)
Man (5)

Status

Employed at RO and RRD (5)
No data on employment in RO (1)
Deceased (1)

No. of publications

0 (6)
1–9 (1)

Projects / Programmes source: ARIS

source: ARIS

Presynaptically toxic phospholipases a2, research tools in neurobiology

Research activity

Code	Science	Field	Subfield
3.03.00	Medical sciences	Neurobiology

Code	Science	Field
B220	Biomedical sciences	Genetics, cytogenetics
B330	Biomedical sciences	Palaeozoology, phylogeny

Keywords

Presynaptic neurotoxin, phospholipase A2, retrotransposon, Bov-B LINE, adaptive evolution, multigene family, horizontal DNA transfer.

Evaluation (rules)

source: COBISS

Evaluation of bibliographic research performance indicators according to ARIS methodology

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (7)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	01088	PhD Vladimir Cotič	Biochemistry and molecular biology	Researcher	2000 - 2001	0
2.	01083	PhD Franc Gubenšek	Biochemistry and molecular biology	Head	2000 - 2001	0
3.	07673	PhD Dušan Kordiš	Biochemistry and molecular biology	Researcher	2000 - 2001	0
4.	00412	PhD Igor Križaj	Biochemistry and molecular biology	Researcher	2000 - 2001	2
5.	18802	PhD Adrijana Leonardi	Biochemistry and molecular biology	Researcher	1999 - 2001	0
6.	11058	PhD Alenka Pariš	Biochemistry and molecular biology	Researcher	1998 - 2001	0
7.	04570	PhD Jože Pungerčar	Biochemistry and molecular biology	Researcher	2000 - 2001	0

Organisations (1)

no.	Code	Research organisation	City	Registration number	No. of publicationsNo. of publications
1.	0106	Jožef Stefan Institute	Ljubljana	5051606000	18

Abstract

Mutants of ammodytoxin will be prepared in order to determine the amino acid residues responsible for the high toxicity of venom phospholipase A2. We will identify parts of the protein surface involved in the interaction with acceptors in synaptosomal membranes and those involved in subsequent interactions with yet unknown structures in the nerve endings. Investigations of the genes of snake venom multigene families are aimed at explaining the accelerated evolution of these genes in which the introns are more conserved than exon, in contrast to Kimura’s neutral theory of evolution. We will also investigate in more detail the evolution and distribution of retrotransposons in reptiles and the horizontal transfer of these repetitive DNA elements between distant vertebrate classes.